Archivos diarios: 24 de junio de 2004

Nada, un chistecillo para animar:

Two ints and a Float are in a bar. They spot an attractive Double on her own. The first int walks up to her. «Hey, baby», he says, «my VM or yours». She slaps him and he walks back dejected.

The second int walks over. «Hey, cute-stuff, can I cook your Beans for breakfast». After a quick slapping, he too walks back.

The Float then ambles over casually. «Were those two primitive types bothering you?», he remarks.

«Yes. I’m so glad you’re here», she says. «They just had no Class!»

Encontrado en Javalobby.

Acabo de cumplir 37 años. Si ese hecho no fuese de por si deprimente:

The ageing of the human brain is a cause of cognitive decline in the elderly and the major risk factor for Alzheimer’s disease. The time in life when brain ageing begins is undefined. Here we show that transcriptional profiling of the human frontal cortex from individuals ranging from 26 to 106 years of age defines a set of genes with reduced expression after age 40. These genes play central roles in synaptic plasticity, vesicular transport and mitochondrial function. This is followed by induction of stress response, antioxidant and DNA repair genes. DNA damage is markedly increased in the promoters of genes with reduced expression in the aged cortex. Moreover, these gene promoters are selectively damaged by oxidative stress in cultured human neurons, and show reduced base-excision DNA repair. Thus, DNA damage may reduce the expression of selectively vulnerable genes involved in learning, memory and neuronal survival, initiating a programme of brain ageing that starts early in adult life.

Gene regulation and DNA damage in the ageing human brain.

Judge Suspected of Masturbating in Court